Targeting receptor–regulator interactions
نویسندگان
چکیده
منابع مشابه
Targeting Platelet–Leukocyte Interactions
The firm adhesion and transplatelet migration of leukocytes on vascular thrombus are dependent on the interaction of the leukocyte integrin Mac-1 (alphaMbeta2, CD11b/CD18) and the platelet counter receptor glycoprotein (GP) Ibalpha. Previous studies have established a central role for the I domain, a stretch of approximately 200 amino acids within the alphaM subunit, in the binding of GP Ibalph...
متن کاملComputational drug design targeting protein-protein interactions.
Novel discoveries in molecular disease pathways within the cell, combined with increasing information regarding protein binding partners has lead to a new approach in drug discovery. There is interest in designing drugs to modulate protein-protein interactions as opposed to solely targeting the catalytic active site within a single enzyme or protein. There are many challenges in this new approa...
متن کاملTargeting protein-protein interactions for drug discovery.
Protein-protein interactions are associated with key activities and pathways in the cell, and in that regard are promising targets for drug discovery. However, in terms of small molecule drugs, this promise has not been realized. The physical nature of many protein-protein interaction surfaces renders them unable to support binding of small drug-like molecules. In addition, there are other uniq...
متن کاملProtein Targeting Interactions in Signalling Processes
Introduction Protein kinase C (PKC) is a family of phospholipiddependent serine-threonine kinases that regulate cell growth and differentiation (reviewed in [ 1 4 ) . PKC is also the major intracellular receptor for tumour-promoting phorbol esters [ 1-31. Molecular cloning and biochemical separation of the individual gene products has led to a classification system for the PKC isoenzymes based ...
متن کاملTargeting Protein-Protein Interactions for Parasite Control
Finding new drug targets for pathogenic infections would be of great utility for humanity, as there is a large need to develop new drugs to fight infections due to the developing resistance and side effects of current treatments. Current drug targets for pathogen infections involve only a single protein. However, proteins rarely act in isolation, and the majority of biological processes occur v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2013
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4092